Transgender people have higher rates of mental health disorders

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Of 10,270 transgender patients identified, 58% (n=5940) had at least one psychiatric diagnosis compared with 13.6% (n=7,311,780) in the control patient population (p<0.0005). Transgender patients had a statistically significant increase in prevalence for all psychiatric diagnoses queried, with major depressive disorder and generalized anxiety disorder being the most common diagnoses (31% and 12%, respectively).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830528/

Finally, 22 studies reported on the prevalence of TG individuals diagnosed with co-morbid mental health disorders or unspecified mental disorders. Our findings coincide with existing research, which indicates TG individuals do experience a higher prevalence of mental health disorders than that of the general population or cisgender individuals.

https://pubmed.ncbi.nlm.nih.gov/36151828/

We found wide gender-related inequalities in the probability of self-reporting a mental health condition, with the highest probabilities among non-binary patients who were transgender (47·21% [95% CI 42·86–51·60]) or preferred not to say their cisgender or transgender identity (32·90% [26·50–40·00]), and among transgender patients who self-described their gender (35·03% [27·39–43·53]).

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(23)00301-8/fulltext

However, after reviewing several letters pointing out methodological limitations of their approach, the authors published a correction noting that this observational study cannot establish the consequences of gender-affirming treatments on mental health. "Only future studies using even stronger methodologies can establish any causal impact of gender-affirming surgery on transgender people's mental health," says study co-author John Pachankis, Susan Dwight Bliss Associate Professor of Public Health at the Yale School of Public Health.

https://ysph.yale.edu/news-article/transgender-individuals-at-greater-risk-of-mental-health-problems/